Intended for UK healthcare professionals only.   CP-487374 | June 2025 © Janssen-Cilag Limited 2025

New first-line treatment option for patients

with EGFR-mutated advanced NSCLC1

Your first
move matters

Discover more about Rybrevant ®

Rybrevant® is indicated: 1

  • in combination with lazertinib for the first-line treatment of adult patients with advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 L858R substitution mutations.
  • in combination with carboplatin and pemetrexed for the treatment of adult patients with advanced non-small cell lung cancer (NSCLC) with EGFR exon 19 deletions or exon 21 L858R substitution mutations after failure of prior therapy including an EGFR tyrosine kinase inhibitor (TKI).
  • in combination with carboplatin and pemetrexed for the first-line treatment of adult patients with advanced NSCLC with activating EGFR exon 20 insertion mutations.
  • as monotherapy for treatment of adult patients with advanced NSCLC with activating EGFR exon 20 insertion mutations, after failure of platinum-based therapy.

LazcluzeTM(lazertinib) is indicated:2

  • in combination with Rybrevant® for the first-line treatment of adult patients withadvanced NSCLC with EGFR exon 19 deletions or exon 21 L858R substitution mutations Abbreviations:

Abbreviations

EGFR, epidermal growth factor receptor; NSCLC, non-small cell lung cancer; TKI, tyrosine kinase inhibitor.

References.

1. Rybrevant® Summary of Product Characteristics. Available from: https://www.medicines.org.uk/emc/product/13084/smpc#gref

2. Lazcluze™ Summary of Product Characteristics (80 mg and 240 mg). Available at: https://www.medicines.org.uk/emc/search?q=lazcluze.

Adverse events should be reported. Reporting forms and information can be found at yellowcard.mhra.gov.uk. Adverse events should also be reported to

Janssen-Cilag Ltd. on 01494 567447 or at dsafety@its.jnj.com.

Prescribing information Rybrevant® & Adverse event reporting > Prescribing information for LazcluzeTM & Adverse event reporting >
Indication, references & abbreviations >